10Suppliers
20Customers
3Debt Items
20Related Chains

Source-Backed Evidence Depth

Spruce Biosciences, Inc. (SPRB) is shown with relationship data already present in ChainSifter's database. Counts below come from stored supply-chain records and filing/source URLs where available; missing source URLs are not filled in or estimated.

34Total relationships
5Distinct source URLs
11High confidence
0.760Average confidence
2026-09-13Latest database update
ChainSifter does not infer unreported suppliers, customers, ownership, acquisitions, debt exposure, revenue dependency, or future supply-chain events on this public page.

Spruce Biosciences, Inc. Suppliers

TickerNameConfidenceEvidence
JEFFERIES-LLC JEFFERIES-LLC 92% Under the Sales Agreement, the Company may offer and sell, from time to time, through Jefferies as its sales agent and/or principal, shares (the “Shares”) of its common stock
LLY Eli Lilly and Company 92% Reciprocal relationship from LLY graph: Reciprocal relationship from SPRB graph: Pursuant to the terms of the Lilly License Agreement, Lilly granted us an exclusive, worldwide, royalty bearing, subli…
LLY Eli Lilly and Company 92% Pursuant to the terms of the Lilly License Agreement, Lilly granted us an exclusive, worldwide, royalty bearing, sublicensable license under certain technology, patent rights, know-how, and proprieta…
BMRN BioMarin Pharmaceutical Inc. 90% Reciprocal relationship from BMRN graph: Reciprocal relationship from SPRB graph: Reciprocal relationship from BMRN graph: Reciprocal relationship from SPRB graph: mmercial sale. In addition, we will…
BMRN BioMarin Pharmaceutical Inc. 90% mmercial sale. In addition, we will also be entitled to receive a royalty for each unit of non-Company manufactured product sold equal to a range of double-digit percentages up to the mid-twenties ba…
HBM-ALPHA-THERAPEUTICS-INC HBM-ALPHA-THERAPEUTICS-INC 90% As consideration, the Company made a one-time upfront payment to HBM of $ 5.0 million in February 2025.
NBIX Neurocrine Biosciences, Inc. 72% her jurisdictions, all of which could seriously harm our business. 85 Table of Contents Item 1B. Unresolv ed Staff Comments. None. For example, cybersecurity risk is addressed as a component of the C…
NBIX Neurocrine Biosciences, Inc. 72% Reciprocal relationship from NBIX graph: Reciprocal relationship from SPRB graph: Reciprocal relationship from NBIX graph: Reciprocal relationship from SPRB graph: Reciprocal relationship from NBIX g…
TWST Twist Bioscience Corporation 72% and time-consuming, and the outcome is unpredictable. Even though we use commonly accepted security measures, the criteria for protection of trade secrets can vary among different jurisdictions. Enfo…
TWST Twist Bioscience Corporation 72% Reciprocal relationship from TWST graph: Reciprocal relationship from SPRB graph: and time-consuming, and the outcome is unpredictable. Even though we use commonly accepted security measures, the cri…

Spruce Biosciences, Inc. Customers

TickerNameConfidenceEvidence
KAKEN-PHARMACEUTICAL-CO-LTD KAKEN-PHARMACEUTICAL-CO-LTD 92% Under the terms of the Collaboration Agreement, the Company granted Kaken the exclusive right to develop, manufacture and commercialize tildacerfont for the treatment of congenital adrenal hyperplasi…
BMRN BioMarin Pharmaceutical Inc. 72% suance of the Avenue Warrant on March 9, 2026, the shares into which the Avenue Warrant will be issued became fixed and therefore the Company reassessed its accounting treatment under ASC 815-40-15-7…
BMRN BioMarin Pharmaceutical Inc. 72% Reciprocal relationship from BMRN graph: Reciprocal relationship from SPRB graph: suance of the Avenue Warrant on March 9, 2026, the shares into which the Avenue Warrant will be issued became fixed a…
LLY Eli Lilly and Company 72% Reciprocal relationship from LLY graph: Reciprocal relationship from SPRB graph: Reciprocal relationship from LLY graph: Reciprocal relationship from SPRB graph: . The following table summarizes the …
LLY Eli Lilly and Company 72% . The following table summarizes the Company's financial assets measured at fair value on a recurring basis by level within the fair value hierarchy (in thousands): December 31, 2025 Total Level 1 Le…
MYGN Myriad Genetics, Inc. 72% governmental bodies to limit the scope of patent protection both inside and outside the United States for disease treatments that prove successful, as a matter of public policy regarding worldwide he…
MYGN Myriad Genetics, Inc. 72% Reciprocal relationship from MYGN graph: Reciprocal relationship from SPRB graph: governmental bodies to limit the scope of patent protection both inside and outside the United States for disease tre…
NBIX Neurocrine Biosciences, Inc. 72% . The following table summarizes the Company's financial assets measured at fair value on a recurring basis by level within the fair value hierarchy (in thousands): December 31, 2025 Total Level 1 Le…
NBIX Neurocrine Biosciences, Inc. 72% Reciprocal relationship from NBIX graph: Reciprocal relationship from SPRB graph: Reciprocal relationship from NBIX graph: Reciprocal relationship from SPRB graph: . The following table summarizes th…
SNYNF Sanofi 72% Reciprocal relationship from SNYNF graph: Reciprocal relationship from SPRB graph: Reciprocal relationship from SNYNF graph: Reciprocal relationship from SPRB graph: Reciprocal relationship from SNYN…
SNYNF Sanofi 72% governmental bodies to limit the scope of patent protection both inside and outside the United States for disease treatments that prove successful, as a matter of public policy regarding worldwide he…
TWST Twist Bioscience Corporation 72% nadvertently incorporated into the technology of others, or are disclosed or used in violation of these agreements. If any of these events occurs or if we otherwise lose protection for our trade secr…
TWST Twist Bioscience Corporation 72% Reciprocal relationship from TWST graph: Reciprocal relationship from SPRB graph: Reciprocal relationship from TWST graph: Reciprocal relationship from SPRB graph: Reciprocal relationship from TWST g…
ABC-LLC ABC-LLC 62% suance of the Avenue Warrant on March 9, 2026, the shares into which the Avenue Warrant will be issued became fixed and therefore the Company reassessed its accounting treatment under ASC 815-40-15-7…
CELLECT-LLC CELLECT-LLC 62% governmental bodies to limit the scope of patent protection both inside and outside the United States for disease treatments that prove successful, as a matter of public policy regarding worldwide he…
DELAWARE-GENERAL-CORPORATION DELAWARE-GENERAL-CORPORATION 62% edly violating the EU GDPR’s cross-border data transfer limitations. Regulators in the United States and other jurisdictions are also increasingly scrutinizing certain data transfers (including to th…
HBM-ALPHA-THERAPEUTICS-INC HBM-ALPHA-THERAPEUTICS-INC 62% . The following table summarizes the Company's financial assets measured at fair value on a recurring basis by level within the fair value hierarchy (in thousands): December 31, 2025 Total Level 1 Le…
HMNC-HOLDING-GMBH HMNC-HOLDING-GMBH 62% . The following table summarizes the Company's financial assets measured at fair value on a recurring basis by level within the fair value hierarchy (in thousands): December 31, 2025 Total Level 1 Le…
LICENSE-AGREEMENTS-BIOMARIN-PHARMACEUTICAL-INC LICENSE-AGREEMENTS-BIOMARIN-PHARMACEUTICAL-INC 62% suance of the Avenue Warrant on March 9, 2026, the shares into which the Avenue Warrant will be issued became fixed and therefore the Company reassessed its accounting treatment under ASC 815-40-15-7…
NASDAQ-STOCK-MARKET-LLC NASDAQ-STOCK-MARKET-LLC 62% trial supplies, and other outside services; o other research and development—expenses associated with business operations, quality and regulatory compliance; and ▪ internal expenses, consisting of pe…

Spruce Biosciences, Inc. Debt Obligations

InstrumentDescriptionConfidenceEvidence
SPRB-DEBT-12710 Warrants outstanding: 57000 90% xbrl warrant detail from xbrl 2025-12-31.
SPRB-DEBT Debt stack $7.1M 90% Market cache reports total debt of $7.1M.
SPRB-DEBT-60637 Xbrl Convertible 90% xbrl convertible detail from xbrl 2026-01-07.

Spruce Biosciences, Inc. Acquisitions

No acquisitions on recordNo completed or pending acquisitions found in our database for Spruce Biosciences, Inc..

Spruce Biosciences, Inc. Ownership

HolderNameConfidenceEvidence
SPRB-OWNER-IKARIAN-CAPITAL-LLC Ikarian Capital, LLC 90% 13F overlay lists Ikarian Capital, LLC as top holder; 32 tracked holders.

Spruce Biosciences, Inc. Extended Supply Chain Network

TickerNameChain IndexHopsRelationship Types
AKTS Aktis Oncology, Inc. 100.00 2
EDSA Edesa Biotech, Inc. 100.00 2
CCEP Coca-Cola Europacific Partners PLC 100.00 2
DSGN Design Therapeutics, Inc. 100.00 2
AZN AstraZeneca PLC 100.00 2
DAWN Day One Biopharmaceuticals Inc 100.00 2
CTNM Contineum Therapeutics, Inc. 100.00 2
SVA Sinovac Biotech Ltd. 100.00 2
BLRX BioLineRx Ltd. 100.00 2
CYTOF Altamira Therapeutics Ltd. 100.00 2
ANL Adlai Nortye Ltd. 100.00 2
ALXO ALX Oncology Holdings Inc. 100.00 2
BIOA BioAge Labs, Inc. 100.00 2
CYTK Cytokinetics, Incorporated 100.00 2
FHTX Foghorn Therapeutics Inc. 100.00 2
ANRO Alto Neuroscience, Inc. 100.00 2
CBIO Crescent Biopharma, Inc. 100.00 2
AXSM Axsome Therapeutics, Inc. 100.00 2
BNBX BNB Plus Corp. 100.00 2
VEEV Veeva Systems Inc. 100.00 2
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SPRB
Unlock SPRB Supply Chain Data
Verified relationships include:
JEFFERIES-LLCJEFFERIES-LLCSupplier92%
LLYEli Lilly and CompanySupplier92%
KAKEN-PHARMACEUTICAL-CO-LTDKAKEN-PHARMACEUTICAL-CO-LTDCustomer92%
BMRNBioMarin Pharmaceutical Inc.Customer72%
+30 more relationships locked
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