6Suppliers
18Customers
2Debt Items
20Related Chains

Source-Backed Evidence Depth

Spyre Therapeutics, Inc. (SYRE) is shown with relationship data already present in ChainSifter's database. Counts below come from stored supply-chain records and filing/source URLs where available; missing source URLs are not filled in or estimated.

27Total relationships
3Distinct source URLs
9High confidence
0.733Average confidence
2026-09-13Latest database update
ChainSifter does not infer unreported suppliers, customers, ownership, acquisitions, debt exposure, revenue dependency, or future supply-chain events on this public page.

Spyre Therapeutics, Inc. Suppliers

TickerNameConfidenceEvidence
EVERCORE-GROUP-L-L-C EVERCORE-GROUP-L-L-C 92% On April 14, 2026, Spyre Therapeutics, Inc. (the “Company”) entered into an underwriting agreement (the “Underwriting Agreement”) with Jefferies LLC, Goldman Sachs & Co. LLC, Evercore Group L.L.C. an…
GOLDMAN-SACHS-CO-LLC GOLDMAN-SACHS-CO-LLC 92% On April 14, 2026, Spyre Therapeutics, Inc. (the “Company”) entered into an underwriting agreement (the “Underwriting Agreement”) with Jefferies LLC, Goldman Sachs & Co. LLC, Evercore Group L.L.C. an…
GUGGENHEIM-SECURITIES-LLC GUGGENHEIM-SECURITIES-LLC 92% On April 14, 2026, Spyre Therapeutics, Inc. (the “Company”) entered into an underwriting agreement (the “Underwriting Agreement”) with Jefferies LLC, Goldman Sachs & Co. LLC, Evercore Group L.L.C. an…
JEFFERIES-LLC JEFFERIES-LLC 92% On April 14, 2026, Spyre Therapeutics, Inc. (the “Company”) entered into an underwriting agreement (the “Underwriting Agreement”) with Jefferies LLC, Goldman Sachs & Co. LLC, Evercore Group L.L.C. an…
PARAGON-THERAPEUTICS-INC PARAGON-THERAPEUTICS-INC 92% On May 14, 2024, the Company and Paragon entered into (i) a license agreement (the “SPY001 License Agreement”), pursuant to which Paragon granted the Company a royalty-bearing, world-wide, exclusive …
WUXI-BIOLOGICS-HONG-KONG-LIMITED WUXI-BIOLOGICS-HONG-KONG-LIMITED 92% Pursuant to a Novation Agreement dated September 19, 2023, by and between us, Paragon and WuXi Biologics, we novated (i) a Biologics Master Services Agreement and (ii) a Cell Line License Agreement.

Spyre Therapeutics, Inc. Customers

TickerNameConfidenceEvidence
JNJ Johnson & Johnson 72% Reciprocal relationship from JNJ graph: Reciprocal relationship from SYRE graph: Reciprocal relationship from JNJ graph: Reciprocal relationship from SYRE graph: Reciprocal relationship from JNJ grap…
JNJ Johnson & Johnson 72% uld any of our product candidates be approved for commercialization, we intend to develop a plan to commercialize them in the United States and other key markets, through internal infrastructure and/…
SNYNF Sanofi 72% Reciprocal relationship from SNYNF graph: Reciprocal relationship from SYRE graph: Reciprocal relationship from SNYNF graph: Reciprocal relationship from SYRE graph: uld any of our product candidates…
SNYNF Sanofi 72% uld any of our product candidates be approved for commercialization, we intend to develop a plan to commercialize them in the United States and other key markets, through internal infrastructure and/…
AEGLEA-BIOTHERAPEUTICS-HOLDINGS-LLC AEGLEA-BIOTHERAPEUTICS-HOLDINGS-LLC 62% quality or expanding access. In the United States, the pharmaceutical industry has been a particular focus of these efforts and has been significantly affected by federal and state legislative initia…
AEGLEA-BIOTHERAPEUTICS-INC AEGLEA-BIOTHERAPEUTICS-INC 62% ubjective, or complex judgments. The communication of critical audit matters does not alter in any way our opinion on the consolidated financial statements, taken as a whole, and we are not, by commu…
ASPEN-MERGER-SUB-I-INC ASPEN-MERGER-SUB-I-INC 62% quality or expanding access. In the United States, the pharmaceutical industry has been a particular focus of these efforts and has been significantly affected by federal and state legislative initia…
COMPANY-PARAGON-THERAPEUTICS-INC COMPANY-PARAGON-THERAPEUTICS-INC 62% f underwriting discounts and other offering costs (the “October 2025 Offering”). The over-allotment option was exercised in full on October 14, 2025 and the transaction closed on October 15, 2025. On…
COMPANY-SEQUOIA-MERGER-SUB-II-LLC COMPANY-SEQUOIA-MERGER-SUB-II-LLC 62% quality or expanding access. In the United States, the pharmaceutical industry has been a particular focus of these efforts and has been significantly affected by federal and state legislative initia…
DELAWARE-GENERAL-CORPORATION DELAWARE-GENERAL-CORPORATION 62% could inadvertently be incorporated into AI model training datasets or disclosed through model inference. As global laws and guidance surrounding AI systems continue to evolve, noncompliance could re…
EQUINITI-TRUST-COMPANY-LLC EQUINITI-TRUST-COMPANY-LLC 62% ial materials, study monitoring and data analysis that could materially adversely impact our business, results of operations and overall financial performance in future periods. As of the filing date…
EU-CLINICAL-TRIALS-EXPERT-GROUP EU-CLINICAL-TRIALS-EXPERT-GROUP 62% quality or expanding access. In the United States, the pharmaceutical industry has been a particular focus of these efforts and has been significantly affected by federal and state legislative initia…
FAIRMOUNT-FUNDS-MANAGEMENT-LLC FAIRMOUNT-FUNDS-MANAGEMENT-LLC 62% f underwriting discounts and other offering costs (the “October 2025 Offering”). The over-allotment option was exercised in full on October 14, 2025 and the transaction closed on October 15, 2025. On…
LIMITED-LIABILITY-COMPANY LIMITED-LIABILITY-COMPANY 62% quality or expanding access. In the United States, the pharmaceutical industry has been a particular focus of these efforts and has been significantly affected by federal and state legislative initia…
PARAPYRE-HOLDING-LLC PARAPYRE-HOLDING-LLC 62% f underwriting discounts and other offering costs (the “October 2025 Offering”). The over-allotment option was exercised in full on October 14, 2025 and the transaction closed on October 15, 2025. On…
PRESENTATION-SPYRE-THERAPEUTICS-INC PRESENTATION-SPYRE-THERAPEUTICS-INC 62% ubjective, or complex judgments. The communication of critical audit matters does not alter in any way our opinion on the consolidated financial statements, taken as a whole, and we are not, by commu…
TRUST-COMPANY-LLC TRUST-COMPANY-LLC 62% ial materials, study monitoring and data analysis that could materially adversely impact our business, results of operations and overall financial performance in future periods. As of the filing date…
USA-LLC USA-LLC 62% Sale of In-Process Research and Development Asset . During the three months ended March 31, 2026, the Company recognized a gain of $30.0 million for an achieved milestone related to the 2023 sale of …

Spyre Therapeutics, Inc. Debt Obligations

InstrumentDescriptionConfidenceEvidence
SYRE-DEBT-12861 Xbrl Convertible 90% xbrl convertible detail from xbrl 2024-12-31.
SYRE-DEBT-12860 Warrants outstanding: 694892 90% xbrl warrant detail from xbrl 2022-12-31.

Spyre Therapeutics, Inc. Acquisitions

No acquisitions on recordNo completed or pending acquisitions found in our database for Spyre Therapeutics, Inc..

Spyre Therapeutics, Inc. Ownership

HolderNameConfidenceEvidence
SYRE-OWNER-FMR-LLC FMR LLC 90% 13F overlay lists FMR LLC as top holder; 199 tracked holders.

Spyre Therapeutics, Inc. Extended Supply Chain Network

TickerNameChain IndexHopsRelationship Types
DSGN Design Therapeutics, Inc. 100.00 2
CSTE Caesarstone Ltd. 100.00 2
BNR Burning Rock Biotech Limited 100.00 2
CCEP Coca-Cola Europacific Partners PLC 100.00 2
BLRX BioLineRx Ltd. 100.00 2
AZN AstraZeneca PLC 100.00 2
BLLN BillionToOne, Inc. 100.00 2
SVA Sinovac Biotech Ltd. 100.00 2
BNRG Brenmiller Energy Ltd 100.00 2
ANRO Alto Neuroscience, Inc. 100.00 2
AORT Artivion, Inc. 100.00 2
AVBP ArriVent BioPharma, Inc. 100.00 2
CYTOF Altamira Therapeutics Ltd. 100.00 2
ANIK Anika Therapeutics, Inc. 100.00 2
BIOA BioAge Labs, Inc. 100.00 2
CYTK Cytokinetics, Incorporated 100.00 2
ANL Adlai Nortye Ltd. 100.00 2
CBIO Crescent Biopharma, Inc. 100.00 2
ALXO ALX Oncology Holdings Inc. 100.00 2
DBVTF DBV TECHNOLOGIES 100.00 2
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SYRE
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Verified relationships include:
EVERCORE-GROUP-L-L-CEVERCORE-GROUP-L-L-CSupplier92%
GOLDMAN-SACHS-CO-LLCGOLDMAN-SACHS-CO-LLCSupplier92%
JNJJohnson & JohnsonCustomer72%
JNJJohnson & JohnsonCustomer72%
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