8Suppliers
13Customers
2Debt Items
20Related Chains

Source-Backed Evidence Depth

Spyre Therapeutics, Inc. (SYRE) is shown with relationship data already present in ChainSifter's database. Counts below come from stored supply-chain records and filing/source URLs where available; missing source URLs are not filled in or estimated.

24Total relationships
4Distinct source URLs
9High confidence
0.755Average confidence
2026-10-28Latest database update
ChainSifter does not infer unreported suppliers, customers, ownership, acquisitions, debt exposure, revenue dependency, or future supply-chain events on this public page.

Spyre Therapeutics, Inc. Suppliers

TickerNameConfidenceEvidence
EVERCORE-GROUP-L-L-C EVERCORE-GROUP-L-L-C 92% On April 14, 2026, Spyre Therapeutics, Inc. (the “Company”) entered into an underwriting agreement (the “Underwriting Agreement”) with Jefferies LLC, Goldman Sachs & Co. LLC, Evercore Group L.L.C. an…
GOLDMAN-SACHS-CO-LLC GOLDMAN-SACHS-CO-LLC 92% On April 14, 2026, Spyre Therapeutics, Inc. (the “Company”) entered into an underwriting agreement (the “Underwriting Agreement”) with Jefferies LLC, Goldman Sachs & Co. LLC, Evercore Group L.L.C. an…
GUGGENHEIM-SECURITIES-LLC GUGGENHEIM-SECURITIES-LLC 92% On April 14, 2026, Spyre Therapeutics, Inc. (the “Company”) entered into an underwriting agreement (the “Underwriting Agreement”) with Jefferies LLC, Goldman Sachs & Co. LLC, Evercore Group L.L.C. an…
JEFFERIES-LLC JEFFERIES-LLC 92% On April 14, 2026, Spyre Therapeutics, Inc. (the “Company”) entered into an underwriting agreement (the “Underwriting Agreement”) with Jefferies LLC, Goldman Sachs & Co. LLC, Evercore Group L.L.C. an…
PARAGON-THERAPEUTICS-INC PARAGON-THERAPEUTICS-INC 92% On May 14, 2024, the Company and Paragon entered into (i) a license agreement (the “SPY001 License Agreement”), pursuant to which Paragon granted the Company a royalty-bearing, world-wide, exclusive …
WUXI-BIOLOGICS-HONG-KONG-LIMITED WUXI-BIOLOGICS-HONG-KONG-LIMITED 92% Pursuant to a Novation Agreement dated September 19, 2023, by and between us, Paragon and WuXi Biologics, we novated (i) a Biologics Master Services Agreement and (ii) a Cell Line License Agreement.
JNJ Johnson & Johnson 72% Reciprocal relationship from JNJ graph: Reciprocal relationship from SYRE graph: Reciprocal relationship from JNJ graph: Reciprocal relationship from SYRE graph: Reciprocal relationship from JNJ grap…
SNYNF Sanofi 72% Reciprocal relationship from SNYNF graph: Reciprocal relationship from SYRE graph: Reciprocal relationship from SNYNF graph: Reciprocal relationship from SYRE graph: Reciprocal relationship from SNYN…

Spyre Therapeutics, Inc. Customers

TickerNameConfidenceEvidence
JNJ Johnson & Johnson 72% uld any of our product candidates be approved for commercialization, we intend to develop a plan to commercialize them in the United States and other key markets, through internal infrastructure and/…
JNJ Johnson & Johnson 72% Reciprocal relationship from JNJ graph: Reciprocal relationship from SYRE graph: uld any of our product candidates be approved for commercialization, we intend to develop a plan to commercialize them…
SNYNF Sanofi 72% uld any of our product candidates be approved for commercialization, we intend to develop a plan to commercialize them in the United States and other key markets, through internal infrastructure and/…
SNYNF Sanofi 72% Reciprocal relationship from SNYNF graph: Reciprocal relationship from SYRE graph: uld any of our product candidates be approved for commercialization, we intend to develop a plan to commercialize th…
AEGLEA-BIOTHERAPEUTICS-HOLDINGS-LLC AEGLEA-BIOTHERAPEUTICS-HOLDINGS-LLC 62% quality or expanding access. In the United States, the pharmaceutical industry has been a particular focus of these efforts and has been significantly affected by federal and state legislative initia…
AEGLEA-BIOTHERAPEUTICS-INC AEGLEA-BIOTHERAPEUTICS-INC 62% ubjective, or complex judgments. The communication of critical audit matters does not alter in any way our opinion on the consolidated financial statements, taken as a whole, and we are not, by commu…
ASPEN-MERGER-SUB-I-INC ASPEN-MERGER-SUB-I-INC 62% quality or expanding access. In the United States, the pharmaceutical industry has been a particular focus of these efforts and has been significantly affected by federal and state legislative initia…
COMPANY-SEQUOIA-MERGER-SUB-II-LLC COMPANY-SEQUOIA-MERGER-SUB-II-LLC 62% quality or expanding access. In the United States, the pharmaceutical industry has been a particular focus of these efforts and has been significantly affected by federal and state legislative initia…
EQUINITI-TRUST-COMPANY-LLC EQUINITI-TRUST-COMPANY-LLC 62% ial materials, study monitoring and data analysis that could materially adversely impact our business, results of operations and overall financial performance in future periods. As of the filing date…
EU-CLINICAL-TRIALS-EXPERT-GROUP EU-CLINICAL-TRIALS-EXPERT-GROUP 62% quality or expanding access. In the United States, the pharmaceutical industry has been a particular focus of these efforts and has been significantly affected by federal and state legislative initia…
LIMITED-LIABILITY-COMPANY LIMITED-LIABILITY-COMPANY 62% quality or expanding access. In the United States, the pharmaceutical industry has been a particular focus of these efforts and has been significantly affected by federal and state legislative initia…
PRESENTATION-SPYRE-THERAPEUTICS-INC PRESENTATION-SPYRE-THERAPEUTICS-INC 62% ubjective, or complex judgments. The communication of critical audit matters does not alter in any way our opinion on the consolidated financial statements, taken as a whole, and we are not, by commu…
TRUST-COMPANY-LLC TRUST-COMPANY-LLC 62% ial materials, study monitoring and data analysis that could materially adversely impact our business, results of operations and overall financial performance in future periods. As of the filing date…

Spyre Therapeutics, Inc. Debt Obligations

InstrumentDescriptionConfidenceEvidence
SYRE-DEBT-12861 Xbrl Convertible 90% xbrl convertible detail from xbrl 2024-12-31.
SYRE-DEBT-12860 Warrants outstanding: 694892 90% xbrl warrant detail from xbrl 2022-12-31.

Spyre Therapeutics, Inc. Acquisitions

No acquisitions on recordNo completed or pending acquisitions found in our database for Spyre Therapeutics, Inc..

Spyre Therapeutics, Inc. Ownership

HolderNameConfidenceEvidence
SYRE-OWNER-FMR-LLC FMR LLC 90% 13F overlay lists FMR LLC as top holder; 199 tracked holders.

Spyre Therapeutics, Inc. Extended Supply Chain Network

TickerNameChain IndexHopsRelationship Types
CCEP Coca-Cola Europacific Partners PLC 100.00 2
DBVTF DBV TECHNOLOGIES 100.00 2
BNRG Brenmiller Energy Ltd 100.00 2
ANIK Anika Therapeutics, Inc. 100.00 2
DSGN Design Therapeutics, Inc. 100.00 2
CSTE Caesarstone Ltd. 100.00 2
BLRX BioLineRx Ltd. 100.00 2
BNR Burning Rock Biotech Limited 100.00 2
AORT Artivion, Inc. 100.00 2
AVBP ArriVent BioPharma, Inc. 100.00 2
CYTOF Altamira Therapeutics Ltd. 100.00 2
BLLN BillionToOne, Inc. 100.00 2
ANL Adlai Nortye Ltd. 100.00 2
AZN AstraZeneca PLC 100.00 2
ALXO ALX Oncology Holdings Inc. 100.00 2
BIOA BioAge Labs, Inc. 100.00 2
CYTK Cytokinetics, Incorporated 100.00 2
ANRO Alto Neuroscience, Inc. 100.00 2
CBIO Crescent Biopharma, Inc. 100.00 2
EDIT Editas Medicine, Inc. 100.00 2
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SYRE
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Verified relationships include:
EVERCORE-GROUP-L-L-CEVERCORE-GROUP-L-L-CSupplier92%
GOLDMAN-SACHS-CO-LLCGOLDMAN-SACHS-CO-LLCSupplier92%
JNJJohnson & JohnsonCustomer72%
JNJJohnson & JohnsonCustomer72%
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